1. Ginkgo Biloba Extract (120 mg)
- Indications: Ginkgo Biloba is commonly used to support cognitive function and enhance memory. It has also been utilized to improve peripheral circulation. citeturn0search3
- Contraindications: Ginkgo Biloba may increase bleeding risk, especially in individuals taking anticoagulant or antiplatelet medications. It is also contraindicated in individuals with known allergies to Ginkgo products. citeturn0search1
- Dosage and Regimen: A typical dose is 120 mg per day, standardized to contain 24% flavonoid glycosides and 6% terpenoids. citeturn0search0
2. 5-Hydroxytryptophan (5-HTP) (20 mg)
- Indications: 5-HTP is a precursor to serotonin and is used to manage conditions like depression, anxiety, and insomnia.
- Contraindications: Concurrent use with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), may lead to serotonin syndrome. It is contraindicated in individuals with carcinoid tumors.
- Dosage and Regimen: Doses typically range from 50 to 100 mg per day. A 20 mg dose is considered low and may be used for mild symptoms or in combination with other therapies.
3. L-Arginine (40 mg)
- Indications: L-Arginine is an amino acid that serves as a precursor to nitric oxide, aiding in vasodilation. It is used to manage conditions like hypertension and erectile dysfunction.
- Contraindications: It should be used cautiously in individuals with herpes infections, as it may promote viral replication. Those with low blood pressure should also exercise caution.
- Dosage and Regimen: Typical doses range from 2 to 6 grams per day. A 40 mg dose is significantly lower and may be used as part of a combination supplement.
4. L-Glutamine (10 mg)
- Indications: L-Glutamine supports immune function and intestinal health. It is used in conditions like irritable bowel syndrome and to support recovery after intense exercise.
- Contraindications: Individuals with liver or kidney disease should use L-Glutamine cautiously.
- Dosage and Regimen: Standard doses range from 5 to 15 grams per day. A 10 mg dose is minimal and likely included for synergistic effects in combination therapy.
5. L-Glutathione (5 mg)
- Indications: L-Glutathione is an antioxidant that protects cells from oxidative stress. It is used to support liver health and in conditions associated with oxidative damage.
- Contraindications: No significant contraindications are noted, but individuals with asthma should use it cautiously.
- Dosage and Regimen: Oral doses typically range from 50 to 600 mg per day. A 5 mg dose is low and may serve as an adjunct in combination supplements.
6. Coenzyme Q10 (10 mg)
- Indications: Coenzyme Q10 plays a role in energy production and functions as an antioxidant. It is used in managing cardiovascular diseases and to improve energy levels.
- Contraindications: Coenzyme Q10 may lower blood pressure, so individuals on antihypertensive medications should monitor their blood pressure.
- Dosage and Regimen: Typical doses range from 30 to 200 mg per day. A 10 mg dose is on the lower end and may be used for maintenance or preventive purposes.
7. Phosphatidylcholine (10 mg)
- Indications: Phosphatidylcholine is a component of cell membranes and supports liver function and cognitive health.
- Contraindications: It is generally considered safe, but high doses may cause gastrointestinal upset.
- Dosage and Regimen: Doses typically range from 300 to 2,400 mg per day. A 10 mg dose is minimal and likely included for synergistic effects.
8. Phosphatidylserine (10 mg)
- Indications: Phosphatidylserine supports cognitive functions, including memory and attention.
- Contraindications: It is generally well-tolerated, but individuals on blood thinners should use it cautiously.
- Dosage and Regimen: Standard doses are around 100 to 300 mg per day. A 10 mg dose is low and may be part of a combination supplement for cognitive support.
9. Vitamin D (25 mcg or 1,000 IU)
- Indications:
- Essential for calcium absorption and bone mineralization, reducing the risk of osteoporosis.
- Supports immune function, helping prevent infections and inflammatory diseases.
- Plays a role in cardiovascular health, muscle function, and neurological well-being.
- May reduce the risk of autoimmune diseases and certain cancers.
- Contraindications:
- Hypercalcemia (High Calcium Levels): Excess vitamin D can lead to calcium buildup in the blood, causing kidney stones, nausea, vomiting, and weakness.
- Sarcoidosis and Granulomatous Diseases: These conditions increase vitamin D sensitivity, potentially leading to hypercalcemia.
- Kidney Disorders: Individuals with chronic kidney disease should monitor vitamin D intake, as impaired kidneys may struggle to regulate calcium levels.
- Certain Medications:
- Thiazide diuretics (e.g., hydrochlorothiazide) may increase the risk of hypercalcemia.
- Glucocorticoids (e.g., prednisone) may reduce vitamin D effectiveness.
- Orlistat and cholestyramine can reduce vitamin D absorption.
- Toxicity Risk: Excessive intake (>4,000 IU daily) can lead to toxicity, causing hypercalcemia, kidney damage, and cardiovascular issues.
10. Vitamin E (36 gm alpha-tocopherol units)
- Indications:
- Antioxidant properties help in protecting cells from oxidative stress.
- Supports immune function and cardiovascular health.
- Used in skin health and anti-aging formulations.
- Contraindications:
- High doses may increase the risk of bleeding, especially in individuals on anticoagulant therapy.
- Should be used with caution in individuals with vitamin K deficiency.
- Dosage and Regimen:
- Recommended dietary allowance (RDA) for adults is 15 mg (22.4 IU) per day.
- A dose of 36 gm (likely a typo, should be mg) is above standard recommendations and may be used for therapeutic purposes.
11. Vitamin C (80 mg, Ascorbic Acid)
- Indications:
- Antioxidant supporting immune function and collagen synthesis.
- Enhances iron absorption.
- Used in skin care for reducing pigmentation and aging signs.
- Contraindications:
- Excess intake (>2,000 mg/day) can cause gastrointestinal distress and kidney stone formation.
- Dosage and Regimen:
- RDA for adults: 75–90 mg/day.
- 80 mg is within the recommended range and supports overall health.
12. Thiamine (Vitamin B1) (25 mg)
- Indications:
- Essential for carbohydrate metabolism and nervous system function.
- Used in preventing thiamine deficiency (beriberi) and Wernicke-Korsakoff syndrome.
- Contraindications:
- No major contraindications, but excessive supplementation may cause mild gastrointestinal discomfort.
- Dosage and Regimen:
- RDA: 1.1–1.2 mg/day.
- A 25 mg dose is higher than RDA, often used in high-dose B-complex supplements for therapeutic purposes.
13. Riboflavin (Vitamin B2) (3 mg)
- Indications:
- Supports energy metabolism and red blood cell production.
- Used for migraine prevention and reducing oxidative stress.
- Contraindications:
- No major side effects, but high doses may cause urine discoloration (harmless).
- Dosage and Regimen:
- RDA: 1.1–1.3 mg/day.
- 3 mg is higher than RDA, often included in B-complex formulas.
14. Niacin (Vitamin B3) (32 mg)
- Indications:
- Helps in cholesterol management and cardiovascular health.
- Supports skin health and nervous system function.
- Contraindications:
- High doses (>50 mg) may cause niacin flush (temporary skin redness and warmth).
- Prolonged high intake can cause liver toxicity.
- Dosage and Regimen:
- RDA: 14–16 mg/day.
- 32 mg is above RDA but within safe therapeutic use.
15. Vitamin B6 (Pyridoxine) (10 mg)
- Indications:
- Essential for neurotransmitter synthesis and immune function.
- Used in treating premenstrual syndrome and nausea during pregnancy.
- Contraindications:
- Long-term high doses (>100 mg/day) may cause nerve damage (neuropathy).
- Dosage and Regimen:
- RDA: 1.3–2 mg/day.
- 10 mg is above RDA, used in therapeutic settings.
16. Folic Acid (Vitamin B9) (400 mcg)
- Indications:
- Essential for DNA synthesis and red blood cell formation.
- Used in pregnancy to prevent neural tube defects.
- Contraindications:
- High doses (>1,000 mcg/day) may mask vitamin B12 deficiency.
- Dosage and Regimen:
- RDA: 400 mcg/day for adults, 600 mcg/day during pregnancy.
17. Vitamin B12 (Cobalamin) (100 mcg)
- Indications:
- Crucial for nerve function and red blood cell production.
- Used to treat pernicious anemia and support brain health.
- Contraindications:
- No major contraindications, but individuals with Leber’s disease should avoid supplementation.
- Dosage and Regimen:
- RDA: 2.4 mcg/day.
- 100 mcg is a high dose, typically used for therapeutic supplementation.
18. Pantothenic Acid (Vitamin B5) (36 mg)
- Indications:
- Supports adrenal function and metabolism.
- Used in skin and hair care.
- Contraindications:
- No major side effects, but excessive intake (>1,000 mg) may cause mild digestive issues.
- Dosage and Regimen:
- RDA: 5 mg/day.
- 36 mg is significantly higher and used in B-complex formulas.
19. Magnesium (75 mg + 2 mg)
- Indications:
- Supports muscle function, nerve transmission, and cardiovascular health.
- Used in migraine prevention and stress management.
- Contraindications:
- Excess intake (>400 mg) may cause diarrhea.
- Caution in kidney disease.
- Dosage and Regimen:
- RDA: 310–420 mg/day.
- 75 mg + 2 mg (total 77 mg) is within an acceptable supplementary range.
20. Iron (8 mg)
- Indications:
- Essential for hemoglobin production and oxygen transport.
- Used in treating anemia.
- Contraindications:
- Excess intake can lead to iron overload and toxicity.
- Dosage and Regimen:
- RDA: 8–18 mg/day.
- 8 mg is within the recommended range.
21. Zinc (15 mg)
- Indications:
- Supports immune function, wound healing, and skin health.
- Used in cold prevention and testosterone support.
- Contraindications:
- Excess intake (>40 mg/day) may cause copper deficiency.
- Dosage and Regimen:
- RDA: 8–11 mg/day.
- 15 mg is a safe supplementary dose.
22. Copper (250 mg, likely a typo; should be mcg or mg)
- Indications:
- Essential for red blood cell formation and iron metabolism.
- Used in preventing anemia.
- Contraindications:
- Excess intake can lead to toxicity and liver damage.
- Dosage and Regimen:
- RDA: 900 mcg/day.
- 250 mg is extremely high and likely an error (should be 250 mcg).
23. Selenium (110 mcg)
- Indications:
- Antioxidant role in thyroid function and immune health.
- Contraindications:
- Excess intake (>400 mcg/day) may cause toxicity.
- Dosage and Regimen:
- RDA: 55 mcg/day.
- 110 mcg is a safe dose for supplementation.
24. Chromium (40 mcg)
- Indications:
- Supports glucose metabolism and insulin sensitivity.
- Dosage and Regimen:
- RDA: 25–35 mcg/day.
- 40 mcg is within a safe range.
25. Iodine (150 mcg)
- Indications:
- Essential for thyroid hormone synthesis.
- Used in preventing goiter and thyroid dysfunction.
- Dosage and Regimen:
Conclusion
This combination therapy includes essential nutrients at safe and effective doses, with each playing a role in overall health, cognition, cardiovascular support, and immunity. However, high doses of certain elements (e.g., copper) should be reviewed for accuracy.