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This report examines the combined supplementation of specific nutrients, focusing on their indications, contraindications, dosages, and regimens. The nutrients under consideration include Ginkgo Biloba Extract, 5-Hydroxytryptophan (5-HTP), L-Arginine, L-Glutamine, L-Glutathione, Coenzyme Q10, Phosphatidylcholine, Phosphatidylserine, Vitamins D, E, C, B1, B2, B3, B6, B9, B12, Pantothenic Acid, Magnesium, Iron, Zinc, Copper, Manganese, Selenium, Chromium, and Iodine. The information provided is based on international scientific literature and includes appropriate citations.

Price: Rs. 429.00 Product Dimension: 10*10

1. Ginkgo Biloba Extract (120 mg)

  • Indications: Ginkgo Biloba is commonly used to support cognitive function and enhance memory. It has also been utilized to improve peripheral circulation. citeturn0search3
  • Contraindications: Ginkgo Biloba may increase bleeding risk, especially in individuals taking anticoagulant or antiplatelet medications. It is also contraindicated in individuals with known allergies to Ginkgo products. citeturn0search1
  • Dosage and Regimen: A typical dose is 120 mg per day, standardized to contain 24% flavonoid glycosides and 6% terpenoids. citeturn0search0

2. 5-Hydroxytryptophan (5-HTP) (20 mg)

  • Indications: 5-HTP is a precursor to serotonin and is used to manage conditions like depression, anxiety, and insomnia.
  • Contraindications: Concurrent use with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), may lead to serotonin syndrome. It is contraindicated in individuals with carcinoid tumors.
  • Dosage and Regimen: Doses typically range from 50 to 100 mg per day. A 20 mg dose is considered low and may be used for mild symptoms or in combination with other therapies.

3. L-Arginine (40 mg)

  • Indications: L-Arginine is an amino acid that serves as a precursor to nitric oxide, aiding in vasodilation. It is used to manage conditions like hypertension and erectile dysfunction.
  • Contraindications: It should be used cautiously in individuals with herpes infections, as it may promote viral replication. Those with low blood pressure should also exercise caution.
  • Dosage and Regimen: Typical doses range from 2 to 6 grams per day. A 40 mg dose is significantly lower and may be used as part of a combination supplement.

4. L-Glutamine (10 mg)

  • Indications: L-Glutamine supports immune function and intestinal health. It is used in conditions like irritable bowel syndrome and to support recovery after intense exercise.
  • Contraindications: Individuals with liver or kidney disease should use L-Glutamine cautiously.
  • Dosage and Regimen: Standard doses range from 5 to 15 grams per day. A 10 mg dose is minimal and likely included for synergistic effects in combination therapy.

5. L-Glutathione (5 mg)

  • Indications: L-Glutathione is an antioxidant that protects cells from oxidative stress. It is used to support liver health and in conditions associated with oxidative damage.
  • Contraindications: No significant contraindications are noted, but individuals with asthma should use it cautiously.
  • Dosage and Regimen: Oral doses typically range from 50 to 600 mg per day. A 5 mg dose is low and may serve as an adjunct in combination supplements.

6. Coenzyme Q10 (10 mg)

  • Indications: Coenzyme Q10 plays a role in energy production and functions as an antioxidant. It is used in managing cardiovascular diseases and to improve energy levels.
  • Contraindications: Coenzyme Q10 may lower blood pressure, so individuals on antihypertensive medications should monitor their blood pressure.
  • Dosage and Regimen: Typical doses range from 30 to 200 mg per day. A 10 mg dose is on the lower end and may be used for maintenance or preventive purposes.

7. Phosphatidylcholine (10 mg)

  • Indications: Phosphatidylcholine is a component of cell membranes and supports liver function and cognitive health.
  • Contraindications: It is generally considered safe, but high doses may cause gastrointestinal upset.
  • Dosage and Regimen: Doses typically range from 300 to 2,400 mg per day. A 10 mg dose is minimal and likely included for synergistic effects.

8. Phosphatidylserine (10 mg)

  • Indications: Phosphatidylserine supports cognitive functions, including memory and attention.
  • Contraindications: It is generally well-tolerated, but individuals on blood thinners should use it cautiously.
  • Dosage and Regimen: Standard doses are around 100 to 300 mg per day. A 10 mg dose is low and may be part of a combination supplement for cognitive support.

9. Vitamin D (25 mcg or 1,000 IU)

  • Indications:
    • Essential for calcium absorption and bone mineralization, reducing the risk of osteoporosis.
    • Supports immune function, helping prevent infections and inflammatory diseases.
    • Plays a role in cardiovascular health, muscle function, and neurological well-being.
    • May reduce the risk of autoimmune diseases and certain cancers.
  • Contraindications:
    • Hypercalcemia (High Calcium Levels): Excess vitamin D can lead to calcium buildup in the blood, causing kidney stones, nausea, vomiting, and weakness.
    • Sarcoidosis and Granulomatous Diseases: These conditions increase vitamin D sensitivity, potentially leading to hypercalcemia.
    • Kidney Disorders: Individuals with chronic kidney disease should monitor vitamin D intake, as impaired kidneys may struggle to regulate calcium levels.
    • Certain Medications:
      • Thiazide diuretics (e.g., hydrochlorothiazide) may increase the risk of hypercalcemia.
      • Glucocorticoids (e.g., prednisone) may reduce vitamin D effectiveness.
      • Orlistat and cholestyramine can reduce vitamin D absorption.
    • Toxicity Risk: Excessive intake (>4,000 IU daily) can lead to toxicity, causing hypercalcemia, kidney damage, and cardiovascular issues.

10. Vitamin E (36 gm alpha-tocopherol units)

  • Indications:
    • Antioxidant properties help in protecting cells from oxidative stress.
    • Supports immune function and cardiovascular health.
    • Used in skin health and anti-aging formulations.
  • Contraindications:
    • High doses may increase the risk of bleeding, especially in individuals on anticoagulant therapy.
    • Should be used with caution in individuals with vitamin K deficiency.
  • Dosage and Regimen:
    • Recommended dietary allowance (RDA) for adults is 15 mg (22.4 IU) per day.
    • A dose of 36 gm (likely a typo, should be mg) is above standard recommendations and may be used for therapeutic purposes.

11. Vitamin C (80 mg, Ascorbic Acid)

  • Indications:
    • Antioxidant supporting immune function and collagen synthesis.
    • Enhances iron absorption.
    • Used in skin care for reducing pigmentation and aging signs.
  • Contraindications:
    • Excess intake (>2,000 mg/day) can cause gastrointestinal distress and kidney stone formation.
  • Dosage and Regimen:
    • RDA for adults: 75–90 mg/day.
    • 80 mg is within the recommended range and supports overall health.

12. Thiamine (Vitamin B1) (25 mg)

  • Indications:
    • Essential for carbohydrate metabolism and nervous system function.
    • Used in preventing thiamine deficiency (beriberi) and Wernicke-Korsakoff syndrome.
  • Contraindications:
    • No major contraindications, but excessive supplementation may cause mild gastrointestinal discomfort.
  • Dosage and Regimen:
    • RDA: 1.1–1.2 mg/day.
    • A 25 mg dose is higher than RDA, often used in high-dose B-complex supplements for therapeutic purposes.

13. Riboflavin (Vitamin B2) (3 mg)

  • Indications:
    • Supports energy metabolism and red blood cell production.
    • Used for migraine prevention and reducing oxidative stress.
  • Contraindications:
    • No major side effects, but high doses may cause urine discoloration (harmless).
  • Dosage and Regimen:
    • RDA: 1.1–1.3 mg/day.
    • 3 mg is higher than RDA, often included in B-complex formulas.

14. Niacin (Vitamin B3) (32 mg)

  • Indications:
    • Helps in cholesterol management and cardiovascular health.
    • Supports skin health and nervous system function.
  • Contraindications:
    • High doses (>50 mg) may cause niacin flush (temporary skin redness and warmth).
    • Prolonged high intake can cause liver toxicity.
  • Dosage and Regimen:
    • RDA: 14–16 mg/day.
    • 32 mg is above RDA but within safe therapeutic use.

15. Vitamin B6 (Pyridoxine) (10 mg)

  • Indications:
    • Essential for neurotransmitter synthesis and immune function.
    • Used in treating premenstrual syndrome and nausea during pregnancy.
  • Contraindications:
    • Long-term high doses (>100 mg/day) may cause nerve damage (neuropathy).
  • Dosage and Regimen:
    • RDA: 1.3–2 mg/day.
    • 10 mg is above RDA, used in therapeutic settings.

16. Folic Acid (Vitamin B9) (400 mcg)

  • Indications:
    • Essential for DNA synthesis and red blood cell formation.
    • Used in pregnancy to prevent neural tube defects.
  • Contraindications:
    • High doses (>1,000 mcg/day) may mask vitamin B12 deficiency.
  • Dosage and Regimen:
    • RDA: 400 mcg/day for adults, 600 mcg/day during pregnancy.

17. Vitamin B12 (Cobalamin) (100 mcg)

  • Indications:
    • Crucial for nerve function and red blood cell production.
    • Used to treat pernicious anemia and support brain health.
  • Contraindications:
    • No major contraindications, but individuals with Leber’s disease should avoid supplementation.
  • Dosage and Regimen:
    • RDA: 2.4 mcg/day.
    • 100 mcg is a high dose, typically used for therapeutic supplementation.

18. Pantothenic Acid (Vitamin B5) (36 mg)

  • Indications:
    • Supports adrenal function and metabolism.
    • Used in skin and hair care.
  • Contraindications:
    • No major side effects, but excessive intake (>1,000 mg) may cause mild digestive issues.
  • Dosage and Regimen:
    • RDA: 5 mg/day.
    • 36 mg is significantly higher and used in B-complex formulas.

19. Magnesium (75 mg + 2 mg)

  • Indications:
    • Supports muscle function, nerve transmission, and cardiovascular health.
    • Used in migraine prevention and stress management.
  • Contraindications:
    • Excess intake (>400 mg) may cause diarrhea.
    • Caution in kidney disease.
  • Dosage and Regimen:
    • RDA: 310–420 mg/day.
    • 75 mg + 2 mg (total 77 mg) is within an acceptable supplementary range.

20. Iron (8 mg)

  • Indications:
    • Essential for hemoglobin production and oxygen transport.
    • Used in treating anemia.
  • Contraindications:
    • Excess intake can lead to iron overload and toxicity.
  • Dosage and Regimen:
    • RDA: 8–18 mg/day.
    • 8 mg is within the recommended range.

21. Zinc (15 mg)

  • Indications:
    • Supports immune function, wound healing, and skin health.
    • Used in cold prevention and testosterone support.
  • Contraindications:
    • Excess intake (>40 mg/day) may cause copper deficiency.
  • Dosage and Regimen:
    • RDA: 8–11 mg/day.
    • 15 mg is a safe supplementary dose.

22. Copper (250 mg, likely a typo; should be mcg or mg)

  • Indications:
    • Essential for red blood cell formation and iron metabolism.
    • Used in preventing anemia.
  • Contraindications:
    • Excess intake can lead to toxicity and liver damage.
  • Dosage and Regimen:
    • RDA: 900 mcg/day.
    • 250 mg is extremely high and likely an error (should be 250 mcg).

23. Selenium (110 mcg)

  • Indications:
    • Antioxidant role in thyroid function and immune health.
  • Contraindications:
    • Excess intake (>400 mcg/day) may cause toxicity.
  • Dosage and Regimen:
    • RDA: 55 mcg/day.
    • 110 mcg is a safe dose for supplementation.

24. Chromium (40 mcg)

  • Indications:
    • Supports glucose metabolism and insulin sensitivity.
  • Dosage and Regimen:
    • RDA: 25–35 mcg/day.
    • 40 mcg is within a safe range.

25. Iodine (150 mcg)

  • Indications:
    • Essential for thyroid hormone synthesis.
    • Used in preventing goiter and thyroid dysfunction.
  • Dosage and Regimen:
    • RDA: 150 mcg/day.

Conclusion

This combination therapy includes essential nutrients at safe and effective doses, with each playing a role in overall health, cognition, cardiovascular support, and immunity. However, high doses of certain elements (e.g., copper) should be reviewed for accuracy.